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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
14.55
Human Site:
T1536
Identified Species:
22.86
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
T1536
G
I
P
K
K
T
T
T
P
K
G
K
G
R
G
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1544
G
I
P
K
K
T
T
T
P
K
G
K
G
R
G
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T1530
G
I
P
K
K
T
T
T
P
K
G
K
G
R
G
Dog
Lupus familis
XP_534241
2041
231068
P1952
G
I
P
K
K
T
T
P
P
K
G
K
G
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
T1523
G
I
P
K
K
T
T
T
P
K
G
K
G
R
G
Rat
Rattus norvegicus
P41516
1526
173202
A1442
K
E
T
K
S
D
S
A
L
N
A
H
V
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
A1835
G
I
P
K
K
T
A
A
P
K
G
K
G
R
G
Chicken
Gallus gallus
O42131
1627
183228
A1539
G
I
P
K
K
T
A
A
P
K
G
K
G
R
G
Frog
Xenopus laevis
NP_001082502
1579
178601
A1495
S
S
D
S
E
D
A
A
P
A
P
K
K
T
S
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S1528
G
T
K
K
P
P
A
S
K
G
S
G
K
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
A1363
E
R
P
G
R
R
Q
A
S
K
K
I
D
Y
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
P1436
K
P
S
T
S
K
K
P
S
P
K
K
A
A
P
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
K1364
E
K
G
K
K
G
A
K
K
P
K
R
N
P
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
R1389
V
S
P
E
K
K
V
R
K
M
R
S
S
P
F
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
R1344
K
L
A
K
K
P
V
R
K
Q
Q
K
V
V
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
93.3
N.A.
100
6.6
N.A.
86.6
86.6
13.3
13.3
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
100
13.3
N.A.
86.6
86.6
20
20
N.A.
20
N.A.
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
34
34
0
7
7
0
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
14
0
0
0
0
0
0
7
0
0
% D
% Glu:
14
7
0
7
7
0
0
0
0
0
0
0
0
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
54
0
7
7
0
7
0
0
0
7
47
7
47
7
47
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% H
% Ile:
0
47
0
0
0
0
0
0
0
0
0
7
0
0
0
% I
% Lys:
20
7
7
74
67
14
7
7
27
54
20
67
14
0
7
% K
% Leu:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% N
% Pro:
0
7
60
0
7
14
0
14
54
14
7
0
0
14
7
% P
% Gln:
0
0
0
0
0
0
7
0
0
7
7
0
0
0
0
% Q
% Arg:
0
7
0
0
7
7
0
14
0
0
7
7
0
47
7
% R
% Ser:
7
14
7
7
14
0
7
7
14
0
7
7
7
7
14
% S
% Thr:
0
7
7
7
0
47
34
27
0
0
0
0
0
7
0
% T
% Val:
7
0
0
0
0
0
14
0
0
0
0
0
14
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _